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dc.contributor.authorOuyang, Gaoliang
dc.contributor.author欧阳高亮
dc.contributor.authorLiu, Min
dc.contributor.authorRuan, Kai
dc.contributor.authorSong, Gang
dc.contributor.authorMao, Yubin
dc.contributor.authorBao, Shideng
dc.date.accessioned2011-08-17T08:28:52Z
dc.date.available2011-08-17T08:28:52Z
dc.date.issued2009
dc.identifier.citationCancer Letters,Volume 281, Issue 2, 28 August 2009, Pages 213-219zh_CN
dc.identifier.issn0304-3835
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.canlet.2009.02.030
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10449
dc.description.abstractPeriostin is a secreted protein and has been shown to be frequently overexpressed in various types of human cancers. We have previously reported that periostin potently promotes metastatic growth of colon cancer by augmenting cell survival. However, little is known about the functions of periostin in non-small-cell lung cancer. Here, we revealed that increased expression of periostin in non-small-cell lung cancer A549 cells was one kind of cellular responses to the stress of chemical-mimic hypoxia, and this effect could be regulated by hypoxia inducible growth factors, such as TGF-alpha and bFGF. We further demonstrated that RTK/PI3-K pathway activated by TGF-alpha and bFGF was evoked in upregulating the expression of periostin, and then periostin promoted the survival of A549 cells under hypoxic microenvironment via activation of Akt/PKB pathway. Therefore, periostin and the pathway that it involved might provide a target for lung cancer treatment. (C) 2009 Elsevier Ireland Ltd. All rights reserved.zh_CN
dc.description.sponsorshipNational Natural Science Foundation of China [30400239, 30570935, 30871242]; Program for New Century Excellent Talents in Xiamen Universityzh_CN
dc.language.isoenzh_CN
dc.publisherELSEVIER IRELAND LTDzh_CN
dc.subjectPeriostinzh_CN
dc.subjectHypoxiazh_CN
dc.subjectApoptosiszh_CN
dc.subjectCell survivalzh_CN
dc.subjectAktzh_CN
dc.titleUpregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathwayzh_CN
dc.typeArticlezh_CN


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