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dc.contributor.authorLi, Yaoyao
dc.contributor.authorZhu, Xiangcheng
dc.contributor.authorDu, Liangcheng
dc.contributor.authorLi, Yaoyao
dc.contributor.authorShen, Yuemao
dc.contributor.author沈月毛
dc.date.accessioned2011-08-16T13:50:19Z
dc.date.available2011-08-16T13:50:19Z
dc.date.issued2009
dc.identifier.citationJ. Nat. Prod., 2009, 72 (7), pp 1328–1330zh_CN
dc.identifier.issn0163-3864
dc.identifier.urihttp://dx.doi.org/doi:10.1021/np900193j
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10439
dc.description.abstractFumonisins and AAL toxins are polyketide-derived mycotoxins produced by several important fungal pathogens of crop plants. The toxins contain a linear, dimethylated polyketide chain, but differ in chain length and methylation positions. Here, we have isolated the major metabolites from a fumonisin null mutant, Fusarium verticillioides strain 5777, that has been transformed with the AAL-toxin polyketide synthase gene (ALT1). The results showed that the metabolites maintained the chain length and methylation pattern of fumonisins. This suggests that the timing and regioselectivity of the methyltransferase of the ALT1 PKS could be reprogrammed in this Fusarium transformant.zh_CN
dc.description.sponsorshipNSF [MCB-0614916]; NIH [RR015468-01]zh_CN
dc.language.isoenzh_CN
dc.publisherAMER CHEMICAL SOCzh_CN
dc.titleIntroduction of the AAL-Toxin Polyketide Synthase Gene ALT1 into FUM1-disrupted Fusarium verticillioides Produces Metabolites with the Fumonisin Methylation Patternzh_CN
dc.typeArticlezh_CN


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