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dc.contributor.authorRuan, Kai
dc.contributor.authorSong, Gang
dc.contributor.author宋刚
dc.contributor.authorOuyang, Gaoliang
dc.contributor.author欧阳高亮
dc.date.accessioned2011-08-16T13:34:25Z
dc.date.available2011-08-16T13:34:25Z
dc.date.issued2009
dc.identifier.citationJournal of Cellular Biochemistry,Volume 107,Issue6,1053-1062,August 2009zh_CN
dc.identifier.issn0730-2312
dc.identifier.urihttp://dx.doi.org/doi:10.1002/jcb.22214
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10437
dc.description.abstractHypoxia has been recognized as one oft he fund a mentally important features of solid tumors and plays a critical role in various cellular and physiologic events, including cell proliferation, survival, angiogenesis, immunosurveillance, metabolism, as well as tumor invasion and metastasis. These responses to hypoxia are at least partially orchestrated by activation of the hypoxia-inducible factors (HIFs). HIF-1 is a key regulator of the response of mammalian cells to oxygen deprivation and plays critical roles in the adaptation of tumor cells to a hypoxic microenvironment. Hypoxia and overexpression of HIF-1 have been associated with radiation therapy and chemotherapy resistance, an increased risk of invasion and metastasis, and a poor clinical prognosis of solid tumors. The discovery of HIF-1 signaling has led to a rapidly increasing understanding of the complex mechanisms involved in tumor hypoxia and has helped greatly in screening novel anticancer agents. In this review, we will first introduce the cellular responses to hypoxia and HIF-1 signaling pathway in hypoxia, and then summarize the multifaceted role of hypoxia in the hallmarks of human cancers. J. Cell. Biochem. 107: 1053-1062, 2009. (C) 2009 Wiley-Liss, Inc.zh_CN
dc.description.sponsorshipNational Natural Science Foundation of China [30400239, 30570935, 30871242]zh_CN
dc.language.isoenzh_CN
dc.publisherWILEY-LISSzh_CN
dc.subjectHYPOXIAzh_CN
dc.subjectHYPOXIA INDUCIBLE FACTORzh_CN
dc.subjectCANCERzh_CN
dc.subjectMICROENVIRONMENTzh_CN
dc.subjectMETASTASISzh_CN
dc.subjectMETABOLISMzh_CN
dc.titleRole of Hypoxia in the Hallmarks of Human Cancerzh_CN
dc.typeArticlezh_CN


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