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dc.contributor.authorWu, Zhaoxian
dc.contributor.authorWang, Mingzi
dc.contributor.authorShen, Yuemao
dc.contributor.author沈月毛
dc.contributor.authorBai, Linquan
dc.date.accessioned2011-08-16T13:23:29Z
dc.date.available2011-08-16T13:23:29Z
dc.date.issued2009
dc.identifier.citationChemistry of Natural Compounds ,Volume 45, Number 3, 333-337,zh_CN
dc.identifier.issn0009-3130
dc.identifier.urihttp://dx.doi.org/doi:10.1007/s10600-009-9350-x
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10436
dc.description.abstractTwo new polyether antibiotics 3, 5 together with three known ones 1, 2, 4 were isolated from Streptomyces hygroscopicus XM201. Based on the unambiguous NMR data assignments, their structures were determined to be 30-acetyl nigericin (1), 1-O-methyl-30-acetyl nigericin (2), 1,29-O-dimethyl-30-acetyl nigericin (3), nigericin (4), and 29-O-methyl abierixin (5), respectively. The antibacterial activities of the nigericin derivatives 1-4 were studied. Compounds 1 and 4 showed strong activities against Staphylococcus aureus ATCC25923 and Bacillus cereus 1126 with MIC of 0.25 mu g/mL and 0.125 mu g/mL, respectively. No inhibitory activities were observed against Escherichia coli CMCC44103 at a concentration of 25 mu g/mL. Only 1 and 4 showed distinguished effects on the protoplast regeneration clones of B. cereus 1126 and E. coli CMCC44103 at a concentration of 1 mu g/mL.zh_CN
dc.description.sponsorshipNational Natural Science Foundation of China [30500632]; Chinese Ministry of Education [306010]; 863 Project [2006AA10A202]zh_CN
dc.language.isoenzh_CN
dc.publisherSPRINGERzh_CN
dc.subjectpolyether antibioticszh_CN
dc.subjectnigericinzh_CN
dc.subjectabierixinzh_CN
dc.subjectStreptomyces hygroscopicus XM201zh_CN
dc.titleStructure-antibacterial relationship of nigericin derivativeszh_CN
dc.typeArticlezh_CN


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