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dc.contributor.authorLin, Tianwei
dc.contributor.author林天伟
dc.contributor.authorLi, Anzhang
dc.contributor.authorZhang, Qian
dc.contributor.authorWu, Caiming
dc.contributor.authorZhang, Rongfu
dc.contributor.authorCai, Qixu
dc.contributor.authorSong, Wenjun
dc.contributor.authorYuen, Kwok-Yung
dc.contributor.authorWang, Gengyan
dc.date.accessioned2011-08-15T13:41:21Z
dc.date.available2011-08-15T13:41:21Z
dc.date.issued2009
dc.identifier.citationVirology,Volume 392, Issue 1, 15 September 2009, Pages 73-81zh_CN
dc.identifier.issn0042-6822
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.virol.2009.06.028
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10426
dc.description.abstractThe interaction between hemagglutinin (HA) and receptors is a kernel in the study of evolution and host adaptation of H1N1 influenza A viruses. The notion that the avian HA is associated with preferential specificity for receptors with Sia alpha 2,3Gal glycosidic linkage over those with Sia alpha 2,6Gal linkage is not all consistent with the available data on H1N1 viruses. By x-ray crystallography, the HA structure of an avian H1N1 influenza A virus, as well as its complexes with the receptor analogs, was determined. The structures revealed no preferential binding of avian receptor analogs over that of the human analog, suggesting that the HA/receptor binding might not be as stringent as is commonly believed in determining the host receptor preference for some subtypes of influenza viruses, such as the H1N1 viruses. The structure also showed difference in glycosylation despite the preservation of related sequences, which may partly contribute to the difference between structures of human and avian origin. (C) 2009 Elsevier Inc. All rights reserved.zh_CN
dc.description.sponsorshipNational Science Foundation of China [30870479]; 111 Project of China [B06016]; Providence Foundation Limited ; Research Fund for Infections Diseases of Hong Kong SAR ; Li Ka Shing Foundationzh_CN
dc.language.isoenzh_CN
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEzh_CN
dc.subjectInfluenzazh_CN
dc.subjectH1N1zh_CN
dc.subjectHemagglutininzh_CN
dc.subjectReceptorzh_CN
dc.subjectStructurezh_CN
dc.titleThe hemagglutinin structure of an avian H1N1 influenza A viruszh_CN
dc.typeArticlezh_CN


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