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dc.contributor.authorWu, Yingying
dc.contributor.authorLu, Chunhua
dc.contributor.authorQian, Xiaoming
dc.contributor.authorHuang, Yaojian
dc.contributor.authorShen, Yuemao
dc.contributor.author沈月毛
dc.date.accessioned2011-08-15T13:18:02Z
dc.date.available2011-08-15T13:18:02Z
dc.date.issued2009
dc.identifier.citationCurrent Microbiology ,Volume 59, Number 4, 475-482zh_CN
dc.identifier.issn0343-8651
dc.identifier.urihttp://dx.doi.org/doi:10.1007/s00284-009-9463-2
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10422
dc.description.abstractOne hundred and fifty endophytic actinomycetes were isolated from three pharmaceutical plants, Annonaceae squamosal, Camptotheca acuminate and Taxus chinensis. Bioactivity test showed that 72.4% of the endophytic actinomycetes displayed inhibition against more than one indicator microorganism. In total, 9.3 and 10.7% showed the cytotoxicity and antioxidant activity, respectively. 3-Amino-5-hydroxybenzoic acid synthase (AHBA), ketosynthase (KS), cytochrome P450 hydroxylases (CYPs) and epoxidase (ES) encoding genes were found in 8.8, 23.8, 2.8 and 11.7% isolates, respectively, by genes screening. The identification based on traditional and molecular methods indicated that diverse genotypes of Streptomyces were distributed in the three pharmaceutical plants, and a few strains of Amycolatopsis were also found in the root of T. chinensis. These results indicated that endophytic actinomycetes associated with pharmaceutical plants could be a promising source of drug leads.zh_CN
dc.description.sponsorshipNational Natural Sciences Foundation of China [30500632]zh_CN
dc.language.isoenzh_CN
dc.publisherSPRINGERzh_CN
dc.titleDiversities Within Genotypes, Bioactivity and Biosynthetic Genes of Endophytic Actinomycetes Isolated from Three Pharmaceutical Plantszh_CN
dc.typeArticlezh_CN


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