• 中文
    • English
  • English 
    • 中文
    • English
  • Login
View Item 
  •   DSpace Home
  • 生命科学学院
  • 生命科学-已发表论文
  • View Item
  •   DSpace Home
  • 生命科学学院
  • 生命科学-已发表论文
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Presenilins regulate the cellular level of the tumor suppressor PTEN

Thumbnail
Full Text
Presenilins regulate the cellular level of the tumor suppressor PTEN.htm (413bytes)
Date
2008
Author
Zhang, Han
Liu, Runzhong
刘润忠
Wang, Ruishan
Hong, Shuigen
Xu, Huaxi
Zhang, Yun-wu
Collections
  • 生命科学-已发表论文 [5901]
Show full item record
Abstract
Alzheimer's Disease (AD) is characterized by amyloid plaques consisting of beta-amyloid (A beta) peptides and neurofibrillary tangles consisting of hyperphosphorylated tau protein. A beta is proteolytically derived from its precursor protein through cleavages by beta-secretase and beta-secretase complex comprising presenilins (PS, PS1/PS2), nicastrin, APH-1 and PEN-2. PS1 is also known to activate the PI3K/Akt cell survival pathway in ay-secretase-independent manner. The tumor suppressor PTEN, which antagonizes the PI3K/Akt pathway, has increasingly been recognized to play a key role in neural functions and its level found reduced in AD brains. Here, we demonstrate that the protein level of PTEN is dramatically reduced in cultured cells and embryonic tissues deficient in PS, and in the cortical neurons of PS1/PS2 conditional double knockout mice. Restoration of PS in PS-deficient cells reverses the reduction of PTEN. Regulation of PTEN by PS is independent of the PS/gamma-secretase activity since impaired gamma-secretase by the gamma-secretase inhibitor treatment or due to nicastrin deficiency has little effect on the protein level of PTEN. Our data suggest an important role for PS in signaling pathways involving PI3K/Akt and PTEN that are crucial for physiological functions and the pathogenesis of multiple diseases. (c) 2006 Elsevier Inc. All rights reserved.
Citation
Neurobiology of Aging,Volume 29, Issue 5, May 2008, Pages 653-660
URI
http://dx.doi.org/doi:10.1016/j.neurobiolaging.2006.11.020
https://dspace.xmu.edu.cn/handle/2288/10415

copyright © 2002-2016  Duraspace  Theme by @mire  厦门大学图书馆  
About | Policies
 

 

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

copyright © 2002-2016  Duraspace  Theme by @mire  厦门大学图书馆  
About | Policies