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dc.contributor.authorGuo, B.
dc.contributor.authorYue, Z-P
dc.contributor.authorHan, B-C
dc.contributor.authorTian, Z
dc.contributor.authorYang, Z-M
dc.contributor.author杨增明
dc.contributor.authorZhao, T-Y
dc.contributor.authorZeng, L.
dc.date.accessioned2011-08-15T12:22:25Z
dc.date.available2011-08-15T12:22:25Z
dc.date.issued2009
dc.identifier.citationEndocrine Reviews June 1, 2000 vol. 21 no. 3 313-345zh_CN
dc.identifier.issn0936-6768
dc.identifier.urihttp://dx.doi.org/doi:10.1210/er.21.3.313
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10410
dc.description.abstractContents Embryo implantation is critical for the successful establishment of pregnancy. Interleukin-11 (IL-11) is essential for adequate decidualization in the mouse and human via binding to the specific IL-11 receptor alpha (IL-11R alpha). But the expression and regulation of IL-11 and IL-11R alpha in the canine endometrium remain unknown. The aim of this study was to investigate the differential expression of IL-11R alpha in canine uterus during early pregnancy and its regulation under different conditions by in situ hybridization. Interleukin-11R alpha mRNA was mainly localized in glandular epithelium in canine uterus. There was a low level of IL-11R alpha expression in the glandular epithelium on days 6, 12 and 17 of pregnancy. On day 20 of pregnancy when embryo implanted, IL-11R alpha mRNA was highly expressed in the glandular epithelium surrounding the embryo, but not in the luminal epithelium and stroma. On day 23 of pregnancy, the expression of IL-11R alpha mRNA maintained a constant level compared with the expression of day 20 and increased on day 28 of pregnancy. During the oestrous cycle, a high level of IL-11R alpha mRNA expression was seen in the oestrous uterus. Progesterone slightly induced the expression of IL-11R alpha mRNA in the ovariectomized canine uterus. These results suggest that IL-11R alpha expression is closely related to canine implantation and up-regulated by progesterone.zh_CN
dc.description.sponsorshipNational Basic Research Program of China [2006CB504005, 2006CB944009]; National Natural Science Foundation of China [30371032, 30571340]; National Hi-Tech Research Development Program of China [2007AA10Z150]zh_CN
dc.language.isoenzh_CN
dc.publisherWILEY-BLACKWELL PUBLISHING, INCzh_CN
dc.titleExpression and Hormonal Regulation of IL-11R alpha in Canine Uterus During Early Pregnancyzh_CN
dc.typeArticlezh_CN


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