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dc.contributor.authorZhao, Yue-Chao
dc.contributor.authorYang, Zeng-Ming
dc.contributor.author杨增明
dc.contributor.authorChi, Yu-Jing(NE Agr Univ)
dc.contributor.authorYu, Yong-Sheng(NE Agr Univ)
dc.contributor.authorLiu, Ji-Long(NE Agr Univ)
dc.contributor.authorSu, Ren-Wei(NE Agr Univ)
dc.contributor.authorMa, Xing-Hong(NE Agr Univ)
dc.contributor.authorShan, Chun-Hua(NE Agr Univ)
dc.date.accessioned2011-08-15T12:19:38Z
dc.date.available2011-08-15T12:19:38Z
dc.date.issued2008
dc.identifier.citationEndocrinology May 1, 2008 vol. 149 no. 5 2325-2332zh_CN
dc.identifier.issn0013-7227
dc.identifier.urihttp://dx.doi.org/doi:10.1210/en.2007-1420
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10409
dc.description.abstractPolyamines are key regulators in cell growth and differentiation. It has been shown that ornithine decarboxylase (Odc) was essential for post-implantation embryo development, and overexpression of spermidine/spermine N1-acetyltransferase will lead to ovarian hypofunction and hypoplastic uteri. However, the expression and function of polyamine-related genes in mouse uterus during early pregnancy are still unknown. In this study we investigated the expression, regulation, and function of polyamine-related genes in mouse uterus during the peri-implantation period. Odc expression was strongly detected at implantation sites and stimulated by estrogen treatment. The expression of Odc antizyme 1 and spermidine/spermine N1-acetyltransferase was also highly shown at implantation sites and regulated by Odc or polyamine level in uterine cells. Embryo implantation was significantly inhibited by alpha-difluoromethylornithine, an Odc inhibitor. Moreover, the reduction of Odc activity caused by alpha-difluoromethylornithine treatment was compensated by the up-regulation of S-adenosylmethionine decarboxylase gene expression. Collectively, our results indicated that the coordinated expression of uterine polyamine-related genes may be important for embryo implantation.zh_CN
dc.language.isoenzh_CN
dc.publisherENDOCRINE SOCzh_CN
dc.titlePolyamines are essential in embryo implantation: Expression and function of polyamine-related genes in mouse uterus during peri-implantation periodzh_CN
dc.typeArticlezh_CN


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