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dc.contributor.authorDu, Xiping
dc.contributor.authorLu, Chunhua
dc.contributor.author鲁春华
dc.contributor.authorLi, Yaoyao
dc.contributor.authorZheng, Zhonghui
dc.contributor.author郑忠辉
dc.contributor.authorSu, Wenjin
dc.contributor.author苏文金
dc.contributor.authorShen, Yuemao
dc.contributor.author沈月毛
dc.date.accessioned2011-08-13T02:16:05Z
dc.date.available2011-08-13T02:16:05Z
dc.date.issued2008
dc.identifier.citationThe Journal of Antibiotics (2008) 61, 250–253zh_CN
dc.identifier.issn0021-8820
dc.identifier.urihttp://dx.doi.org/doi:10.1038/ja.2008.37
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10403
dc.description.abstractTwo new 10-membered macrolides, named Phomolides A (1) and B (2), and one new derivative of benzofuran (3) were isolated from the culture of Phomopsis sp. hzla01-1, and their structures were elucidated based on spectroscopic analyses, particularly 2D NMR experiments. Compounds 1, 2 and 3 showed significant antimicrobial activities against Escherichia coli CMCC44103, Candida alhicans AS2.538, Saccharomyces cerevisiae ATCC9763 with MICs 5 similar to 10 mu g/ml. The most significant, compound 3 showed strong activity against Bacillus subtilis CMCC63501 with the MIC value 1.25 mu g/ml. None of the three compounds showed significant cytotoxicity against the HeLa cell line at 10 mu g/ml.zh_CN
dc.language.isoenzh_CN
dc.publisherJAPAN ANTIBIOTICS RESEARCH ASSOCzh_CN
dc.subject10-membered macrolidezh_CN
dc.subjectbenzofuranzh_CN
dc.subjectPhomopsis sp hzla01-1zh_CN
dc.subjectMICzh_CN
dc.titleThree new antimicrobial metabolites of Phomopsis sp.zh_CN
dc.typeArticlezh_CN


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