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Three new antimicrobial metabolites of Phomopsis sp.

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Three new antimicrobial metabolites of Phomopsis sp..htm (405bytes)
Date
2008
Author
Du, Xiping
Lu, Chunhua
鲁春华
Li, Yaoyao
Zheng, Zhonghui
郑忠辉
Su, Wenjin
苏文金
Shen, Yuemao
沈月毛
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  • 生命科学-已发表论文 [5901]
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Abstract
Two new 10-membered macrolides, named Phomolides A (1) and B (2), and one new derivative of benzofuran (3) were isolated from the culture of Phomopsis sp. hzla01-1, and their structures were elucidated based on spectroscopic analyses, particularly 2D NMR experiments. Compounds 1, 2 and 3 showed significant antimicrobial activities against Escherichia coli CMCC44103, Candida alhicans AS2.538, Saccharomyces cerevisiae ATCC9763 with MICs 5 similar to 10 mu g/ml. The most significant, compound 3 showed strong activity against Bacillus subtilis CMCC63501 with the MIC value 1.25 mu g/ml. None of the three compounds showed significant cytotoxicity against the HeLa cell line at 10 mu g/ml.
Citation
The Journal of Antibiotics (2008) 61, 250–253
URI
http://dx.doi.org/doi:10.1038/ja.2008.37
https://dspace.xmu.edu.cn/handle/2288/10403

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