Three new antimicrobial metabolites of Phomopsis sp.
Date
2008Author
Du, Xiping
Lu, Chunhua
鲁春华
Li, Yaoyao
Zheng, Zhonghui
郑忠辉
Su, Wenjin
苏文金
Shen, Yuemao
沈月毛
Collections
- 生命科学-已发表论文 [5901]
Abstract
Two new 10-membered macrolides, named Phomolides A (1) and B (2), and one new derivative of benzofuran (3) were isolated from the culture of Phomopsis sp. hzla01-1, and their structures were elucidated based on spectroscopic analyses, particularly 2D NMR experiments. Compounds 1, 2 and 3 showed significant antimicrobial activities against Escherichia coli CMCC44103, Candida alhicans AS2.538, Saccharomyces cerevisiae ATCC9763 with MICs 5 similar to 10 mu g/ml. The most significant, compound 3 showed strong activity against Bacillus subtilis CMCC63501 with the MIC value 1.25 mu g/ml. None of the three compounds showed significant cytotoxicity against the HeLa cell line at 10 mu g/ml.