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dc.contributor.authorBouvree, Karine(INSERM)
dc.contributor.authorLarrivee, Bruno(INSERM)
dc.contributor.authorDeLafarge, Benjamin(INSERM)
dc.contributor.authorFreitas, Catarina(INSERM)
dc.contributor.authorMathivet, Thomas(INSERM)
dc.contributor.authorEichmann, Anne(INSERM)
dc.contributor.authorPardanaud, Luc(INSERM)
dc.contributor.authorBreant, Christiane(Coll France)
dc.contributor.authorTessier-Lavigne, Marc(Genentech Inc)
dc.contributor.authorLv, Xiang ( Beijing Union Med Coll)
dc.contributor.authorYuan, Li
dc.contributor.author袁立
dc.date.accessioned2011-08-12T13:27:15Z
dc.date.available2011-08-12T13:27:15Z
dc.date.issued2008
dc.identifier.citationDevelopmental Biology,Volume 318, Issue 1, 1 June 2008, Pages 172-183zh_CN
dc.identifier.issn0012-1606
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.ydbio.2008.03.023
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10401
dc.description.abstractNetrin-1 is a bifunctional axonal guidance cue, capable of attracting or repelling developing axons via activation of receptors of the deleted in colorectal cancer (DCC) and uncoordinated 5 (UNC5) families, respectively. In addition to its role in axon guidance, Netrin-1 has been implicated in angiogenesis, where it may also act as a bifunctional cue. Attractive effects of Netrin-1 on endothelial cells appear to be mediated by an as yet unknown receptor, while repulsion of developing blood vessels in mouse embryos is mediated by the UNC5B receptor. To explore evolutionary conservation of vascular UNC5B expression and function, we have cloned the chick unc5b homologue. Chick and quail embryos showed unc5b expression in arterial EC and sprouting angiogenic capillaries. To test if Netrin-1 displayed pro- or anti-angiogenic activities in the avian embryo, we grafted cell lines expressing recombinant chick or human Netrin-1 at different stages of development. Netrin-1 expressing cells inhibited angiogenic sprouting of unc5b expressing blood vessels, but had no pro-angiogenic activity at any stage of development examined. Netrin-1 also had no effect on the recruitment of circulating endothelial precursor cells. Taken together, these data indicate that vascular unc5b expression and function is conserved between chick and mice. (C) 2008 Elsevier Inc. All rights reserved.zh_CN
dc.language.isoenzh_CN
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEzh_CN
dc.subjectvessel guidancezh_CN
dc.subjectUNC5Bzh_CN
dc.subjectangiogenesiszh_CN
dc.subjectsproutingzh_CN
dc.subjectCEC/EPCzh_CN
dc.titleNetrin-1 inhibits sprouting angiogenesis in developing avian embryoszh_CN
dc.typeArticlezh_CN


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