Paeciloxanthone, a new cytotoxic xanthone from the marine mangrove fungus Paecilomyces sp (Tree1-7)
Chan, Wing-Lai（Hong Kong Polytech Univ）
Wen, Lu（ Sun Yat Sen Zhongshan Univ）
Lin, Yong-Cheng（ Sun Yat Sen Zhongshan Univ）
She, Zhi-Gang（ Sun Yat Sen Zhongshan Univ）
Du, Dun-Shuai（ Sun Yat Sen Zhongshan Univ）
- 生命科学－已发表论文 
The metatrophic fungus Paecilomyces sp. (Tree1-7) was isolated from an estuarine mangrove from the Taiwan Strait. The methanol extract of the fungal mycelium exhibited cytotoxicity against hepG2. Paeciloxanthone (1), a new xanthone, and the known compounds emodin (2) and chrysophanol (3), were isolated from the extract. Their structures were elucidated by spectroscopic experiments. Paeciloxanthone (1) exhibited in vitro cytotoxicity against hepG2 (IC50 = 1.08 mu g/mL), acetylcholi-neesterase (AChE) inhibitory (IC50 2.25 mu g/mL) and antimicrobial activities.