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MicroRNAs: Novel regulators in the hallmarks of human cancer

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MicroRNAs Novel regulators in the hallmarks of human cancer .htm (413bytes)
Date
2009
Author
Ruan, Kai
Fang, Xiaoguang
Ouyang, Gaoliang
欧阳高亮
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  • 生命科学-已发表论文 [5901]
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Abstract
MicroRNAs (miRNAs) are small non-coding RNAs of 18-25 nucleotides in length that function as negative regulators. miRNAs post-transcriptionally regulate gene expression by either inhibiting mRNA translation or inducing mRNA degradation, and participate in a wide variety of physiological and pathological cellular processes. Recent reports have revealed that the deregulation of miRNAs correlates with various human cancers and is involved in the initiation and progression of human cancers. miRNAs can act as oncogenes or tumor suppressors to inhibit the expression of cancer-related target genes and to promote or suppress tumorigenesis in various tissues. Therefore, abnormal miRNA expression can be regarded as a common feature of human cancers, and the identification of miRNAs and their respective targets may provide potential diagnostic and prognostic tumor biomarkers and new therapeutic strategies to treat cancers. In the present review, we discuss the emerging roles of miRNAs in the hallmarks of human cancers. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
Citation
Cancer Letters,Volume 285, Issue 2, 28 November 2009, Pages 116-126
URI
http://dx.doi.org/doi:10.1016/j.canlet.2009.04.031
https://dspace.xmu.edu.cn/handle/2288/10366

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