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dc.contributor.authorFeng, Chen-Guo
dc.contributor.authorChen, Jie
dc.contributor.authorYe, Jian-Liang
dc.contributor.authorRuan, Yuan-Ping
dc.contributor.author阮源萍
dc.contributor.authorZheng, Xiao
dc.contributor.authorHuang, Pei-Qiang
dc.contributor.author黄培强
dc.date.accessioned2011-08-01T13:35:38Z
dc.date.available2011-08-01T13:35:38Z
dc.date.issued2006-06
dc.identifier.citationTETRAHEDRON,2006,62(31):7459-7465zh_CN
dc.identifier.issn0040-4020
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.tet.2006.05.013
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10358
dc.description.abstractStarting from lactone-amide 8, easily derived from L-glutamic acid, enantioselective syntheses of (S)-tetrahydrofuran 2-carboxamide derivative 2 and a protected (S)-3-hydroxypiperidin-2-one (3) are reported. The building block 3 was converted to (2S,3R)-3-hydroxypipecolamide (6) by a three-step procedure. A solvent altered H-bonding capacity leading to a highly chemoselective tosylation of the primary hydroxyl group in the presence of an alpha-hydroxy-carboxamide was observed. (c) 2006 Elsevier Ltd. All rights reserved.zh_CN
dc.language.isoenzh_CN
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDzh_CN
dc.subject3-hydroxypipecolamidezh_CN
dc.subject3-hydroxypiperidin-2-onezh_CN
dc.subjectbuilding blockzh_CN
dc.subjecthydrogen bondzh_CN
dc.subjectchemoselective reactionzh_CN
dc.titleSyntheses of enantio-enriched chiral building blocks from L-glutamic acidzh_CN
dc.typeArticlezh_CN


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