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dc.contributor.authorLin, Sheng-Cai
dc.contributor.author林圣彩
dc.contributor.authorDu, Xiping
dc.contributor.authorZhan, Yanyan
dc.contributor.authorChen, Hangzi
dc.contributor.authorLiu, Jingjing
dc.contributor.authorZhao, Bixing
dc.contributor.authorHuang, Danhong
dc.contributor.authorLi, Guideng
dc.contributor.authorXu, Qingyan
dc.contributor.author徐庆妍
dc.contributor.authorZhang, Mingqing
dc.contributor.authorCheng, Zhe
dc.contributor.authorZhang, Lianru
dc.contributor.author张连茹
dc.contributor.authorLi, Qinxi
dc.contributor.author李勤喜
dc.contributor.authorLi, Shaowei
dc.contributor.author李少伟
dc.contributor.authorZheng, Zhonghui
dc.contributor.author郑忠辉
dc.contributor.authorSong, Siyang
dc.contributor.author宋思扬
dc.contributor.authorHuang, Yaojian
dc.contributor.author黄耀坚
dc.contributor.authorYe, Zhiyun
dc.contributor.author叶志云
dc.contributor.authorSu, Wenjin
dc.contributor.author苏文金
dc.contributor.authorShen, Yuemao
dc.contributor.author沈月毛
dc.contributor.authorWu, Qiao
dc.contributor.author吴乔
dc.contributor.authorWeimer, Bart C(Utah State Univ)
dc.contributor.authorChen, Dong(Utah State Univ)
dc.date.accessioned2011-07-31T08:18:33Z
dc.date.available2011-07-31T08:18:33Z
dc.date.issued2008
dc.identifier.citationNature Chemical Biology 4, 548 - 556 (2008)zh_CN
dc.identifier.issn1552-4450
dc.identifier.urihttp://dx.doi.org/doi:10.1038/nchembio.106
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10351
dc.description.abstractNuclear orphan receptor Nur77 has important roles in many biological processes. However, a physiological ligand for Nur77 has not been identified. Here, we report that the octaketide cytosporone B (Csn-B) is a naturally occurring agonist for Nur77. Csn-B specifically binds to the ligand-binding domain of Nur77 and stimulates Nur77-dependent transactivational activity towards target genes including Nr4a1 (Nur77) itself, which contains multiple consensus response elements allowing positive autoregulation in a Csn-B-dependent manner. Csn-B also elevates blood glucose levels in fasting C57 mice, an effect that is accompanied by induction of multiple genes involved in gluconeogenesis. These biological effects were not observed in Nur77-null (Nr4a1(-/-)) mice, which indicates that Csn-B regulates gluconeogenesis through Nur77. Moreover, Csn-B induced apoptosis and retarded xenograft tumor growth by inducing Nur77 expression, translocating Nur77 to mitochondria to cause cytochrome c release. Thus, Csn-B may represent a promising therapeutic drug for cancers and hypoglycemia, and it may also be useful as a reagent to increase understanding of Nur77 biological function.zh_CN
dc.description.sponsorshipNational Natural Science Fund of China [30630070, 30425014, 30325044]; Ministry of Science and Technology [2006CB503905, 2004CB518800, 2007CB914402]; Ministry of Education [706036, 306010, 705030]zh_CN
dc.language.isoenzh_CN
dc.publisherNATURE PUBLISHING GROUPzh_CN
dc.titleCytosporone B is an agonist for nuclear orphan receptor Nur77zh_CN
dc.typeArticlezh_CN


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