New BZLF1 sequence variations in EBV-associated undifferentiated nasopharyngeal carcinoma in southern China
Wu, Xu-Li（Shenzhen Univ）
Ji, Kun-Mei（Shenzhen Univ）
Li, Chun-Lin（Haikou City Hosp）
Meng, Guang（Haikou City Hosp）
- 生命科学－已发表论文 
The viral lytic gene BZLF1 triggers replication of the Epstein-Barr virus (EBV), which is commonly found in nasopharyngeal carcinoma (NPC). Here, RT-PCR revealed five new BZLF1 variants in 8 of 12 NPC and 4 of 12 non-NPC nasopharyngeal biopsies from an NPC-endemic area in southern China. The deduced peptide sequence of the dominant BZLF1 variant differed by 11 amino acids from that of the prototypical strain B95.8 (V01555). Anti-ZEBRA antibody levels were higher in NPC than that in non-NPC patients (P < 0.001). These findings demonstrated a dominant BZLF1 variant in southern Chinese EBV-associated NPC and non-NPC patients.
出处Archives of Virology，Volume 153, Number 10, 1949-1953