Show simple item record

dc.contributor.authorMing, Yan-Lin
dc.contributor.authorSong, Gang
dc.contributor.authorCai, Qiu-Feng
dc.contributor.authorMao, Yu-Bin
dc.contributor.authorBao, Shi-Deng
dc.contributor.author鲍仕登
dc.contributor.authorOuyang, Gao-Liang
dc.contributor.author欧阳高亮
dc.date.accessioned2011-07-31T04:05:33Z
dc.date.available2011-07-31T04:05:33Z
dc.date.issued2008
dc.identifier.citationCancer Science,Vol 99 Issue 10,pp1901-1907zh_CN
dc.identifier.issn1347-9032
dc.identifier.urihttp://dx.doi.org/doi:10.1111/j.1349-7006.2008.00911.x
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10335
dc.description.abstractOsteopontin (OPN) is a secreted, integrin-binding matrix phosphorylated glycoprotein that is overexpressed in many advanced cancers. However, the functional mechanisms by which OPN contributes to the development of ovarian cancer are poorly understood. Here, we reveal that acquired expression of OPN by HO-8910 ovarian cancer cells greatly promoted the progression of ovarian cancer. OPN expression dramatically increased the colony formation of ovarian cancer cells in vitro and tumor growth in vivo. Under the stress induced by serum depletion or curcumin treatment, OPN expression promoted the survival of ovarian cells through preventing stress-induced apoptosis. At the molecular level, both endogenous and exogenous OPN expression activated the PI3-K/Akt survival pathway and dramatically decreased p53 expression under serum depletion. In addition, HIF-1 alpha was induced in OPN-producing cells under normoxia. Furthermore, we also found that inhibition of the PI3-K/Akt pathway attenuated OPN-mediated HIF-1 alpha up-regulation in ovarian cancer cells. Taken together, these results indicate that OPN can increase the survival of ovarian cancer cells under stress conditions in vitro and promote the late progression of ovarian cancer in vivo, and the survival-promoting functions of OPN are mediated through Akt activation and the induction of HIF-1 alpha expression. (Cancer Sci 2008; 99: 1901-1907)zh_CN
dc.description.sponsorshipNational Natural Science Foundation of China [30370307, 30400239, 30570935]; Program for New Century Excellent Talents in Xiamen Universityzh_CN
dc.language.isoenzh_CN
dc.publisherBLACKWELL PUBLISHINGzh_CN
dc.titleOsteopontin promotes ovarian cancer progression and cell survival and increases HIF-1 alpha expression through the PI3-K/Akt pathwayzh_CN
dc.typeArticlezh_CN


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record