Acute trimethyltin exposure induces oxidative stress response and neuronal apoptosis in Sebastiscus marmoratus

Abstract

Trimethyltin (TMT) is a well-documented neurotoxicant that affects the function of central nervous system (CNS). In this study, we studied the neurotoxicity of TMT on the brain of marine fish Sebastiscus marmoratus. Our results showed that TMT acute exposure induced brain cell apoptosis in the telencephalon, optic tectum and cerebellum. In addition, we observed increased production of reactive oxygen species (ROS), nitric oxide (NO) and one asparate-specific cysteinyl protease named caspase-3 which are often associated with the processes of cell apoptosis, in the brain of S. marmoratus after acute treatment of TMT. Our results indicated that TMT induces neurotoxicity and oxidative stress in marine fish S. marmoratus. Our results suggested that TMT exposure in the environment may affect fish behaviors including schooling, sensory and motorial learnings, based on the observation of cell apoptosis in the cerebral regions. (C) 2008 Elsevier B.V. All rights reserved.