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dc.contributor.authorZuo, Zhenghong
dc.contributor.author左正宏
dc.contributor.authorLi, Bowen
dc.contributor.author李博文
dc.contributor.authorWang, Chonggang
dc.contributor.author王重刚
dc.contributor.authorYe, Kai
dc.contributor.authorYu, Ang
dc.contributor.authorChen, Yixin
dc.contributor.author陈奕欣
dc.date.accessioned2011-07-30T09:49:34Z
dc.date.available2011-07-30T09:49:34Z
dc.date.issued2008
dc.identifier.citationMarine Environmental Research,Volume 66, Issue 5, December 2008, Pages 548-552zh_CN
dc.identifier.issn0141-1136
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.marenvres.2008.09.001
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10322
dc.description.abstractEffects of exposure to polychlorinated biphenyls (PCBs) on Sebastiscus marmoratus were investigated using a suppression subtractive hybridization method. A total of 108 gene sequences were identified as having the potential for being differentially expressed, and 45 could be identified with homologous database sequences. Functions with which they were associated included long-term potentiation and neurotransmitter release, neuroendocrine, mitosis and cell proliferation, energy-related metabolism, general metabolism. signal protein, hemopoiesis system, immune system, and structure. The expression of 17 of these genes was analyzed in the brain using real time fluorescent quantitative PCR. The present study provided a basis for studying the response of fish to PCB exposure and allowed the characterization of new potential neurotoxicol biomarkers of PCB contamination in seawater. (C) 2008 Elsevier Ltd. All rights reserved.zh_CN
dc.description.sponsorshipNational Natural Science Foundation [40606027]; State Key Laboratory of Marine Environmental Science, Xiamen University, China [MEL0606]zh_CN
dc.language.isoenzh_CN
dc.publisherELSEVIER SCI LTDzh_CN
dc.subjectPolychlorinated biphenylszh_CN
dc.subjectNeurotoxicityzh_CN
dc.subjectSebastiscus marmoratuszh_CN
dc.subjectSuppression subtractive hybridization libraryzh_CN
dc.subjectReal time PCRzh_CN
dc.titleDifferential gene expression in the brain of Sebastiscus marmoratus in response to exposure to polychlorinated biphenyls (PCBs)zh_CN
dc.typeArticlezh_CN


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