Exogenous leptin promotes the recovery of regressed ovary in fasted ducks
- 生命科学－已发表论文 
The present study was undertaken to examine the effect of administered recombinant mouse leptin on the recovery of regressed ovary in fasted ducks. Twenty-eight ducks were divided into live groups: fed ad libitum (control: n =5). fasted control (FC; n=5), fasted + low dose of leptin (F+ L; n=5). fasted +medium close of leptin (F+ M; n =5) and fasted + high dose of leptin (F+ H; n=3). All four fasted groups were fasted for 2 clays and then ad libitum and the clucks were treated with leptin at doses of 0 (control and FC). 50 (F+L), 250 (F+ M) and 10()0 (F+H) mu g/kg body weight/day on day 3-5. Results showed that a moderate close of leptin (250 mu g/kg, body weight/day) injected during the re-feeding period: (i) promoted the recovery of the regressed ovary as evidenced by an increase in ovary weight and recovery of yellow hierarchical follicles; (ii) elevated the plasma 17 beta-estradiol (E-2) level; (iii) increased the mRNA levels of ovary follicle-stimulating hormone receptor (FSHR). luteinizing hormone receptor (LHR) and estrogen receptor-beta (ER-beta). Furthermore, the results also showed that a high close of leptin (1000 mu g/kg body weight/day) may have a negative effect on the recovery of the regressed ovary. In conclusion, this Study indicates that. in clucks. leptin may be involved in the recovery of the regressed ovary caused by 2 days of fasting. This effect may be related to increased plasma E-2 levels and stimulation of the mRNA levels of ovarian FSHR. LHR and especially ER-beta. (C) 2008 Elsevier B.V. All rights reserved.
出处Animal Reproduction Science，Volume 110, Issues 3-4, February 2009, Pages 306-318