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dc.contributor.authorLiang, Ying
dc.contributor.authorLi, Qi-Fu
dc.contributor.author李祺福
dc.contributor.authorZhang, Xiu-Yan
dc.contributor.authorShi, Song-Lin
dc.contributor.author石松林
dc.contributor.authorJing, Guang-Jun
dc.date.accessioned2011-07-30T01:25:38Z
dc.date.available2011-07-30T01:25:38Z
dc.date.issued2009
dc.identifier.citationJournal of Cellular Biochemistry,Vol 106 Issue 5 ,pp849-857zh_CN
dc.identifier.issn0730-2312
dc.identifier.urihttp://dx.doi.org/doi:10.1002/jcb.22052
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10287
dc.description.abstractTo investigate the alteration of nuclear matrix proteins (NMPs) during the differentiation of neuroblastoma SK-N-SH cells induced by retinoic acid (RA), differentiation markers were detected by immunocytochemistry and NMPs were selectively extracted and subjected to two-dimensional gel electrophoresis analysis. Immunocytochemical observation demonstrated that the expression of neuronal markers was upregulated in SK-N-SH cells following RA treatment. Meanwhile, 52 NMPs (41 of which were identified) changed significantly during SK-N-SH differentiation; four of these NMPs were further confirmed by immunoblotting. This study suggests that the differentiation of neuroblastoma cells was accompanied by the altered expression of neuronal markers and NMPs. The presence of some differentially expressed NMPs was related to the proliferation and differentiation of neuroblastomas. Our results may help to reveal the relationship between NMPs and neuroblastoma carcinogenesis and reversion, as well as elucidate the regulatory principals driving neural cell proliferation and differentiation. J. Cell. Biochem. 106: 849-857, 2009. (C) 2009 Wiley-Liss, Inc.zh_CN
dc.language.isoenzh_CN
dc.publisherWILEY-LISSzh_CN
dc.subjectNUCLEAR MATRIX PROTEINSzh_CN
dc.subjectDIFFERENTIATIONzh_CN
dc.subjectHUMAN NEUROBLASTOMAzh_CN
dc.subjectRETINOIC ACIDzh_CN
dc.subjectDIFFERENTIAL EXPRESSIONzh_CN
dc.titleDifferential Expression of Nuclear Matrix Proteins During the Differentiation of Human Neuroblastoma SK-N-SH Cells Induced by Retinoic Acidzh_CN
dc.typeArticlezh_CN


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