Comparative and evolutionary aspects of macromolecular translocation across membranes
Tartakoff, Alan M.（Case Western Reserve Univ）
- 生命科学－已发表论文 
Membrane barriers preserve the integrity of organelles of eukaryotic cells, yet the genesis and ongoing functions of the same organelles requires that their limiting membranes allow import and export of selected macromolecules. Multiple distinct mechanisms are used for this purpose, only some of which have been traced to prokaryotes. Some can accomodate both monomeric and also large heterooligomeric cargos. The best characterized of these is nucleocytoplasmic transport. This synthesis compares the unidirectional and bidirectional mechanisms of macromolecular transport of the endoplasmic reticulum, mitochondria, peroxisomes and the nucleus, calls attention to the powerful experimental approaches which have been used for their elucidation, discusses their regulation and evolutionary origins, and highlights relatively unexplored areas. (C) 2009 Elsevier Ltd. All rights reserved.