Seven Novel Linear Polyketides from Xylaria sp NCY2

Abstract

Seven novel polyketides, namely, 1-(xylarenone A)xylariate A (1), xylarioic acid B (2), xylariolide A (3), xylariolide B (4), xylariolide C (5), methyl xylariate C (6), and xylariolide D(7), together with the known one taiwapyrone (8), were isolated from the endophytic fungal strain xylaria sp. NCY2 of Torreya jackii CHUN. Their structures were elcidated by spectroscopic analyses, including 1D- and 2D-NMR experiments, and on the basis of HR-Q-TOF mass spectometry. Antitumor and antibacterial assays of compounds 1-8 were carried out, which show moderate activities.