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dc.contributor.author周朝晖
dc.contributor.author颜文斌
dc.contributor.author张凤章
dc.contributor.author万惠霖
dc.contributor.author蔡启瑞
dc.date.accessioned2011-07-15T08:44:49Z
dc.date.available2011-07-15T08:44:49Z
dc.date.issued2001-03
dc.identifier.citation厦门大学学报(自然科学版),2001,40(2):320-329zh_CN
dc.identifier.issn0438-0479
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10177
dc.description作者简介:周朝晖,(1964-),男,教授;蔡启瑞(1914-), 男, 院士. 通讯联系人; e-mail: krtsai@xmu.edu.cnzh_CN
dc.description.abstract[中文文摘]固氮酶是某些微生物在常温常压下固氮成氨的主要催化剂 ,其催化机理和化学模拟是国际上长期致力研究的对象 .尽管人们已经揭示了固氮酶催化活性中心铁钼辅基 (Fe Mo- co) Mo Fe7S9(R-高柠檬酸 )的结构 ,然而 ,有关 Fe Mo- co生物合成的详细途径和其中包含的钼铁转移和利用 ;固氮酶在哪些活性位和按什么模式结合 N2 ,C2 H2 、CO等多种底物或抑制剂 ;以及其中涉及的电子和质子传递过程等许多问题 ,至今尚有待解决 .本文将综述这些问题的研究进展和厦门大学固氮组最近五年来的相关研究工作.[英文文摘]Nitrogenase catalyzes the reduction of dinitrogen to ammonia coupled to the hydrolysis of ATP, which is central to the process of biological nitrogen fixation. X-ray crystallographic structures has revealed its catalytic metal center FeMo-cofactor as a cage structure of MoFe7S9(R-homocitrate), in which the homocitrate coordinate bidentately to molybdenum. Recent efforts towards establishing the mechanism of activation of nitrogen around the metal center and the early biosynthesis process of FeMo-co are reviewed,which reflect a combination of structural,spectroscopic,synthetic, biochemical and theoretical approaches to this challenging problem pursued especially from the nitrogen fixation group of Xiamen University.zh_CN
dc.description.sponsorship国家自然科学基金(29933040);高等学校博士学科点基金;教育部骨干教师基金; 厦门大学科学研究基金资助项目zh_CN
dc.language.isozhzh_CN
dc.publisher《厦门大学学报(自然科学版)》编辑部zh_CN
dc.subject固氮酶zh_CN
dc.subject铁钼辅基zh_CN
dc.subject铁钒辅基zh_CN
dc.subject化学模拟zh_CN
dc.subject催化作用zh_CN
dc.subject高柠檬酸zh_CN
dc.subject柠檬酸zh_CN
dc.subject不对称zh_CN
dc.subjectnitrogenasezh_CN
dc.subjectiron molybdenum cofactorzh_CN
dc.subjectiron vanadium cofactorzh_CN
dc.subjectchemical modelingzh_CN
dc.subjecthomocitric acidzh_CN
dc.subjectcitric acidzh_CN
dc.subjectchiralzh_CN
dc.subjectconfiguration assignmentzh_CN
dc.title固氮酶催化作用机理及其化学模拟zh_CN
dc.title.alternativeCatalytic Mechanism of Nitrogen Reduction by Nitrogenase and its Chemical Modelingzh_CN
dc.typeArticlezh_CN


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