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dc.contributor.authorOuyang, Gaoliang
dc.contributor.author欧阳高亮
dc.contributor.authorWang, Zhe
dc.contributor.authorFang, Xiaoguang
dc.contributor.authorLiu, Jia
dc.contributor.authorYang, Chaoyong James
dc.date.accessioned2011-07-13T04:07:07Z
dc.date.available2011-07-13T04:07:07Z
dc.date.issued2010
dc.identifier.citationCellular and Molecular Life Sciences ,Volume 67, Number 15, 2605-2618zh_CN
dc.identifier.issn1420-682X
dc.identifier.urihttp://dx.doi.org/doi:10.1007/s00018-010-0338-2
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10132
dc.description.abstractThe epithelial to mesenchymal transition (EMT) is a highly conserved cellular program that allows polarized, well-differentiated epithelial cells to convert to unpolarized, motile mesenchymal cells. EMT is critical for appropriate embryogenesis and plays a crucial role in tumorigenesis and cancer progression. Recent studies revealed that there is a direct link between the EMT program and the gain of epithelial stem cell properties. EMT is sufficient to induce a population with stem cell characteristics from well-differentiated epithelial cells and cancer cells. In this review, we briefly introduce the biology of EMT inducers and transcription factors in tumorigenesis and then focus on the role of these key players of the EMT in generating and maintaining cancer stem cells.zh_CN
dc.description.sponsorshipNational Nature Science Foundation of China [30570935, 30871242]; Science Planning Program of Fujian Province [2009J1010]; National Basic Research Program of China [2010CB732402]zh_CN
dc.language.isoenzh_CN
dc.publisherBIRKHAUSER VERLAG AGzh_CN
dc.subjectEpithelial-mesenchymal transition (EMT)zh_CN
dc.subjectCancer stem cellzh_CN
dc.subjectStemnesszh_CN
dc.subjectTumorigenesiszh_CN
dc.subjectMetastasiszh_CN
dc.subjectTranscription factorzh_CN
dc.subjectTumor microenvironmentzh_CN
dc.subjectExtracellular matrix (ECM)zh_CN
dc.titleMolecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cellszh_CN
dc.typeArticlezh_CN


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