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dc.contributor.authorXu, Yunling
dc.contributor.authorYuan, Li
dc.contributor.author袁立
dc.contributor.authorPardanaud, Luc(Inst Natl Sante & Rech Med)
dc.contributor.authorLarrivee, Bruno(Inst Natl Sante & Rech Med)
dc.contributor.authordel Toro, Raquel(Inst Natl Sante & Rech Med)
dc.contributor.authorSuchting, Steven(Inst Natl Sante & Rech Med)
dc.contributor.authorEichmann, Anne(Inst Natl Sante & Rech Med)
dc.date.accessioned2011-07-12T11:51:27Z
dc.date.available2011-07-12T11:51:27Z
dc.date.issued2010
dc.identifier.citationJOURNAL OF CELL BIOLOGY,January 11, 2010 // JCB vol. 188 no. 1 115-130zh_CN
dc.identifier.issn0021-9525
dc.identifier.urihttp://dx.doi.org/doi:10.1083/jcb.200903137
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10103
dc.description.abstractVascular sprouting is a key process-driving development of the vascular system. In this study, we show that neuropilin-2 (Nrp2), a transmembrane receptor for the lymphangiogenic vascular endothelial growth factor C (VEGF-C), plays an important role in lymphatic vessel sprouting. Blocking VEGF-C binding to Nrp2 using antibodies specifically inhibits sprouting of developing lymphatic endothelial tip cells in vivo. In vitro analyses show that Nrp2 modulates lymphatic endothelial tip cell extension and prevents tip cell stalling and retraction during vascular sprout formation. Genetic deletion of Nrp2 reproduces the sprouting defects seen after antibody treatment. To investigate whether this defect depends on Nrp2 interaction with VEGF receptor 2 (VEGFR2) and/or 3, we intercrossed heterozygous mice lacking one allele of these receptors. Double-heterozygous nrp2vegfr2 mice develop normally without detectable lymphatic sprouting defects. In contrast, double-heterozygote nrp2vegfr3 mice show a reduction of lymphatic vessel sprouting and decreased lymph vessel branching in adult organs. Thus, interaction between Nrp2 and VEGFR3 mediates proper lymphatic vessel sprouting in response to VEGF-C.zh_CN
dc.description.sponsorshipInstitut National de la Sante et de la Recherche Medicale ; Agence Nationale de la Recherche (Neuroscience, blanc) ; Association pour la Recherche contre le Cancer ; Institut National du Cancer ; Institut de France (Cino del Duca) ; European Community [LSHG-CT-2004-503573]zh_CN
dc.language.isoenzh_CN
dc.publisherROCKEFELLER UNIV PRESSzh_CN
dc.titleNeuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3zh_CN
dc.typeArticlezh_CN


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