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A novel immunoassay for PreS1 and/or core-related antigens for detection of HBsAg variants

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A novel immunoassay for PreS1 andor core-related antigens for detection of HBsAg variants.htm (413bytes)
Date
2010-09
Author
Yuan, Quan
Ge, Shengxiang
Xiong, Junhui
Yan, Qiang
Shih, J. Wai-Kuo
Zhang, Jun
张君
Xia, Ningshao
夏宁绍
Li, Zhuo(Capital Med Univ, Youan Hosp)
Hao, Xiaoke(Fourth Mil Med Univ, Xijing Hosp)
Tian, Deying(Huazhong Univ Sci & Technol)
Niu, Jianjun(Ctr Dis Control & Prevent Xiamen)
Su, Zhijun( Fujian Med Univ, Quanzhou Hosp 1)
Chen, Changrong
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  • 生命科学-已发表论文 [5901]
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Abstract
A novel immunoassay that detects simultaneously hepatitis B virus (HBV) PreS1 and/or core-related antigens was developed and evaluated for its potential for detecting hepatitis B surface antigen (HBsAg) variants. The detection limits of the assay was 10(2.9 +/- 05) copies/mL (mean +/- SD) for HBsAg-positive sera with different genotypes, and 10(3.5 +/- 1.2) copies/mL for HBsAg variants sera. The specificity of the assay was 99.9% (95% Cl: 99.7-99.9%, 4551 healthy individuals). The sensitivities were 93.9% (95% Cl: 92.8-94.9%), 59.3% (95% Cl: 38.7-77.6%) and 80% (95% CI: 44.4-97.5%) in three independent groups which include: 2065 hepatitis patients, 27 patients with occult hepatitis B and 10 HBsAg variants, respectively. In addition, a novel premature stop code mutation at position 112 of HBsAg was observed in two patients with chronic hepatitis B with different genotypes. (C) 2010 Elsevier B.V. All rights reserved.
Citation
Journal of Virological Methods,Volume 168, Issues 1-2, Pages 108-113
URI
http://dx.doi.org/doi:10.1016/j.jviromet.2010.04.029
https://dspace.xmu.edu.cn/handle/2288/10094

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