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dc.contributor.authorGuo, Yun-Ji
dc.contributor.authorPan, Zhi-Zhen
dc.contributor.authorHu, Yong-Hua
dc.contributor.authorLiu, Feng-Jiao
dc.contributor.authorShi, Yan
dc.contributor.authorChen, Qing-Xi
dc.contributor.author陈清西
dc.contributor.authorChen, Chao-Qi(Peking Univ, Coll Urban & Environm Sci)
dc.contributor.authorYan, Jiang-Hua
dc.date.accessioned2011-07-12T00:59:23Z
dc.date.available2011-07-12T00:59:23Z
dc.date.issued2010
dc.identifier.citationApplied Biochemistry and Biotechnology ,Volume 162, Number 6, 1564-1573zh_CN
dc.identifier.issn0273-2289
dc.identifier.urihttp://dx.doi.org/doi:10.1007/s12010-010-8938-8
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10087
dc.description.abstractThe effects of fatty acids, octanoic acid, (2E, 4E)-hexa-2,4-dienoic acid, hexanoic acid, (2E)-but-2-enoic acid, and butyric acid on the activities of mushroom tyrosinase have been investigated. The results showed that the fatty acids can potently inhibit both monophenolase activity and diphenolase activity of tyrosinase, and that the unsaturated fatty acids exhibited stronger inhibitory effect against tyrosinase than the corresponding saturated fatty acids, and the inhibitory effects were enhanced with the extendability of the fatty acid chain. For the monophenolase activity, the fatty acids could not only lengthen the lag period, but also decrease the steady-state activities. For the diphenolase activity, fatty acids displayed reversible inhibition. Kinetic analyses showed that octanoic acid and hexanoic acid were mixed-type inhibitors and ( 2E,4E)-hexa-2,4-dienoic acid and (2E)-but-2-enoic acid were noncompetitive inhibitors. The inhibition constants have been determined and compared.zh_CN
dc.description.sponsorshipNational Key Technology R & D Program of China [2007BAD07B06]; Natural Science Foundation of China [30570408]; Science and Technology Foundation of Fujian Province [2004N002, 2007N0051]zh_CN
dc.language.isoenzh_CN
dc.publisherHUMANA PRESS INCzh_CN
dc.subjectTyrosinasezh_CN
dc.subjectFatty acidzh_CN
dc.subjectMonophenolase activityzh_CN
dc.subjectDiphenolase activityzh_CN
dc.subjectInhibition kineticszh_CN
dc.titleInhibitory Effects of Fatty Acids on the Activity of Mushroom Tyrosinasezh_CN
dc.typeArticlezh_CN


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