Now showing items 2429-2448 of 5878

    • T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells 

      Li, Gang; Yang, Qianting; Zhu, Yibei; Wang, Hong-Rui; Chen, Xinchun; Zhang, Xueguang; Lu, Binfeng; 王洪睿 (PUBLIC LIBRARY SCIENCE, 2013-Jun 2)
      Memory T cells are composed of effector, central, and memory stem cells. Previous studies have implicated that both T-bet and Eomes are involved in the generation of effector and central memory CD8 T cells. The exact role ...
    • TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling 

      Gang, L.; Kang, Y. J.; Han, J. H.; Herschman, H. R.; Stefani, E.; Wang, Y. B.; 韩家淮 (2006)
      Stress-activated mitogen-activated protein (MAP) kinase p38 mediates stress signaling in mammalian cells via threonine and tyrosine phosphorylation in its conserved TGY motif by upstream MAP kinase kinases (MKKs). In ...
    • TAB1 beta (transforming growth Factor-beta-activated protein kinase 1-binding protein 1 beta), a novel splicing variant of TAB1 that interacts with p38 alpha but not TAK1 

      Ge, B. X.; Xiong, X. S.; Jing, Q.; Mosley, J. L.; Filose, A.; Bian, D. F.; Huang, S.; Han, J. H.; 韩家淮 (2003)
      The mitogen-activated protein kinases (MAPKs) play an important role in a variety of biological processes. Activation of MAPKs is mediated by phosphorylation on specific regulatory tyrosine and threonine sites. We have ...
    • Tachyplesin activates the classic complement pathway to kill tumor cells 

      Chen, J. G.; Xu, X. N.; Underhfll, C. B.; Yang, S. M.; Wang, L. P.; Chen, Y. X.; Hong, S. G.; Creswell, K.; Zhang, L. R.; 陈奕欣 (2005-06-01)
      Tachyplesin is a small, cationic peptide that possesses antitumor properties. However, little is known about its action mechanism. We used phage display to identify a protein that interacted with tachyplesin and isolated ...
    • TAK1-dependent signaling requires functional interaction with TAB2/TAB3 

      Besse, A.; Lamothe, B.; Campos, A. D.; Webster, W. K.; Maddineni, U.; Lin, S. C.; Wu, H.; Darnay, B. G.; 林圣彩 (2007)
      Transforming growth factor beta-activated kinase 1 (TAX1), a member of the MAPKKK family, was initially described to play an essential role in the transforming growth factor beta-signaling pathway, but recent evidence has ...
    • Tandem conjugation of enzyme and antibody on silica nanoparticle for enzyme immunoassay 

      Ke, Rongqin; Yang, Wei; Xia, Xiaohu; Xu, Ye; Li, Qingge; 李庆阁 (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010-11-01)
      We present a new type of enzyme-antibody conjugate that simplifies the labeling procedure and increases the sensitivity of enzyme-linked immunosorbent assay (ELISA). The conjugates were prepared through layer-by-layer ...
    • Tannin dynamics in hypocotyls and pericarps of Aegiceras corniculatum fruits during dry storage 

      Xiang, Ping; Lin, Yi-Ming; 林益明; Xiang, Cheng; Lin, Peng; 林鹏; Ju, Shu ( Univ Miami, Dept Biol) (ACADEMIC JOURNALS, 2010-07)
      In this study, we investigated the changes in total phenolics, extractable condensed tannins (ECT), protein noncovalent bound condensed tannins (PNBCT) and irreversible covalent bound condensed tannins (ICBCT) in the ...
    • Tannin dynamics in hypocotyls and pericarps of Aegiceras corniculatum fruits during dry storage 

      Xiang, Ping; Lin, Yi-Ming; 林益明; Xiang, Cheng; Lin, Peng; 林鹏; Ju, Shu(Univ Miami, Dept Biol) (ACADEMIC JOURNALS, 2010-07)
      Thorn. like Pd nanoparticles (Pd-n(thorn)) were synthesized at room temperature by a reduction of PdCl2 with L. ascorbic acid and with choline chloride as a stabilizer. Characterization of Pd-n(thorn) by transmission ...
    • Tannin dynamics of propagules and leaves of Kandelia candel and Bruguiera gymnorrhiza in the Jiulong River Estuary, Fujian, China 

      Lin, YM; 林益明; Liu, JW; Xiang, P; Lin, P; 林鹏; Ye, GF; Sternberg, LDSL (SPRINGER, 2006)
      Changes in the total phenolics, condensed tannins (CT), protein-precipitable phenolics content and protein precipitation capacity were determined on a series of mangrove leaves from two true viviparous mangrove species ...
    • Tannins and nitrogen dynamics in mangrove leaves at different age and decay stages (Jiulong River Estuary, China) 

      Lin, Yi Ming; 林益明; Liu, Jin Wen; Xiang, Ping; Lin, Peng; 林鹏; Ding, Zhen Hua; 丁振华; da Silveira Lobo Sternberg, Leonel( Univ Miami, Dept Biol, Coral Gables, FL 33124 USA) (SPRINGER, 2007)
      Changes in the total phenolics, condensed tannins (CT), protein-precipitable phenolics content and protein precipitation capacity were determined on mangrove leaves representing a range of maturation and senescence in the ...
    • Tannins from Canarium album with potent antioxidant activity 

      Zhang, Liang-liang; Lin, Yi-ming; 林益明 (ZHEJIANG UNIV, 2008)
      The contents of total phenolics and extractable condensed tannins in the leaves, twigs and stem bark of Canarium album were determined. The structural heterogeneity of condensed tannings from stem bark was characterized ...
    • Targeting Nuclear Receptors with Marine Natural Products 

      Yang, Chunyan; Li, Qianrong; Li, Yong; 杨春燕; 李勇 (MDPI AG, 2014 FEB)
      Nuclear receptors (NRs) are important pharmaceutical targets because they are key regulators of many metabolic and inflammatory diseases, including diabetes, dyslipidemia, cirrhosis, and fibrosis. As ligands play a pivotal ...
    • Tat介导外源蛋白引入活细胞 

      陈亚兵; 温龙平 (1996)
      本文在介绍外源大分子引入细胞的方法及HIV-1反式激活因子TAT蛋白的结构基础上概述了TAT蛋白介导的外源蛋白进入活细胞的方法,并进一步地对其作用机制进行了探讨,认为TAT介导的外源大分子引入细胞系统在研究细胞生命活动及临床医学上有重要的意义。
    • Tat碱性结构域-Bcl-Xs融合蛋白与细胞短暂共培养可诱导细胞程序性死亡 

      郭淑贞; 陈亚兵; 张军; 谢小燕; 杨海杰; 温龙平; 夏宁邵 (2000-10-10)
      艾滋病毒的 Tat蛋白碱性结构域的 1 3个氨基酸的多肽能自主穿越细胞膜并将与之融合表达的其他蛋白带入细胞 .为探讨融合表达的蛋白是否可保持原有的主要生物学功能 ,将 Bcl- Xs蛋白与 Tat碱性结构域在大肠杆菌中融合表达 ,重组蛋白 Tat- Bcl- Xs与 CHO、CNE、Hela和 772 1细胞共温育一段时间后 ,细胞均可见明显生长抑制 ,同时细胞变圆、变小、细胞核收缩 ,并有染色体凝聚、边缘化 ,或细胞核分裂为小核的现象 ...
    • Taxol from Tubercularia sp strain TF5, an endophytic fungus of Taxus mairei 

      Wang, JF; Li, GL; Lu, HY; Zheng, ZH; 郑忠辉; Huang, YJ; 黄耀坚; Su, WJ; 苏文金 (ELSEVIER SCIENCE BV, 2000)
      The diterpenoid taxol is an important anticancer agent used widely in the clinic. The purpose or this work was to identify a taxol-producing endophytic Fungus (strain TF5) isolated from Taxus mairei and study its anticancer ...
    • TB-IGRA与TST检测菌培阳性肺结核患者比较 

      张向东(厦门市疾病预防控制中心); 郑蓉蓉(厦门市疾病预防控制中心); 何水珍(厦门市疾病预防控制中心); 熊君辉; 葛胜祥; 张军; 牛建军(厦门市疾病预防控制中心) (《中国人兽共患病学报》编辑部, 2012-05)
      [中文文摘]目的比较结核分枝杆菌γ-干扰素体外释放试验(TB-IGRA)与结核菌素皮肤试验(TST)在临床上用于检测MTB感染者的应用价值。方法 TB-IGRA与TST平行检测对147例菌培阳性肺结核患者,并分析年龄、性别和是否接种卡介苗对各自检测性能的影响。TST分别比较红肿硬块直径≥5mm(TST5)和≥15mm(TST15)者。结果 TB-IGRA和TST5的检出率分别为80.3%(118/147)和78.2%(115/147), ...
    • TB-IGRA试验在调查本地健康中老年人群结核分支杆菌特异性γ-干扰素本底值的应用 

      刘秀兰; 袁中行; 符美娟 (2011)
      目的:探索本地区45岁以上健康中老年人群血浆结核分支杆菌特异性γ-干扰素本底值,为Tb-IgrA定量试验广泛应用于结核病的临床诊断、疗效观察提供本底值参照依据。方法:选取100位45岁以上健康中老年人,结核分枝杆菌(MTb)γ-干扰素体外释放定量试验测定其血浆中特异性γ-干扰素含量。结果:盐城市100位健康中老年人血浆特异性γ-干扰素含量为0.1 Pg/Ml~7.1 Pg/Ml,中位数为1.1 Pg/Ml。结论:本地区健康中老年血浆中特 ...
    • Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer 

      Yamagishi, H.; Maeda, J.; Hu, T. H.; McAnally, J.; Conway, S. J.; Kume, T.; Meyers, E. N.; Yamagishi, C.; Srivastava, D.; 胡天惠 (2003)
      Haploinsufficiency of Tbx1 is likely a major determinant of cardiac and craniofacial birth defects associated with DiGeorge syndrome. Although mice deficient in Tbx1 exhibit pharyngeal and aortic arch defects, the developmental ...
    • TEMPORAL AND SPATIAL EXPRESSION OF LEUKEMIA INHIBITORY FACTOR IN RABBIT UTERUS DURING EARLY-PREGNANCY 

      Yang, Z. M.; Le, S. P.; Chen, D. B.; Harper, M. J. K.; 杨增明 (1994)
      Leukemia inhibitory factor (LIF) has been shown to play an important role in the implantation of mouse blastocysts. The present study was designed to document the appearance of LIF in the rabbit uterus during early pregnancy ...
    • Tenacibaculum xiamenense sp nov, an algicidal bacterium isolated from coastal seawater 

      Li, Yi; Wei, Jun; Yang, Caiyun; Lai, Qiliang; Chen, Zhangran; Li, Dong; Zhang, Huajun; Tian, Yun; Zheng, Wei; Zheng, Tianling; 田蕴; 郑天凌 (SOC GENERAL MICROBIOLOGY, 2013)
      A Gram-stain-negative, elongated rod-shaped, yellow-pigmented, aerobic bacterial strain, designated WJ-1(T), was isolated from coastal seawater in Xiamen, Fujian province, China. Phylogenetic analysis based on 16S rRNA ...