Now showing items 1844-1863 of 5878

    • P-TEFb的功能及其活性调控机制 

      胡向明; 陈瑞川 (2010-06-15)
      P-TEFb是调控真核基因转录延伸的核心转录因子之一,为大多数mRNA转录所必需;与艾滋病、心肌肥大和肿瘤均有密切关系;目前有关P-TEFb的生物学功能及其活性调控机制仍在不断的发现之中。在细胞内,P-TEFb以无活性和可被募集两种复合体存在,并且两种复合体之间可互相转化,以严格维持细胞内P-TEFb的总体活性水平。近年的研究已逐渐揭示P-TEFb活性调控的分子模式,以及调控细胞内P-TEFb活化的信号和分子机理。本文综述近年有关P-T ...
    • p150(Glued), dynein, and microtubules are specifically required for activation of MKK3/6 and p38 MAPKs 

      Cheung, P. Y.; Zhang, Y.; Long, J. F.; Lin, S. C.; Zhang, M. J.; Jiang, Y.; Wu, Z. G.; 林圣彩 (2004)
      To look for regulators of the mitogen-activated protein kinase ( MAPK) kinase 6 (MKK6), a yeast two-hybrid screen was initiated using MKK6 as bait. p150(Glued) dynactin, a key component of the cytoplasmic dynein-dynactin ...
    • p300/CBP及其相关因子PCAF与转录调控 

      林娟玉; 黄翔; 韩爱东 (2009)
      P300/CbP及其相关因子PCAf具有乙酰转移酶活性,能通过乙酰化组蛋白和非组蛋白的方式参与基因的转录调控.同时,它们也能介导多种转录因子.与大多数典型的转录辅激活子相同,它们能在转录因子和基本转录复合物之间起到桥梁作用.P300/CbP与细胞周期调控、细胞凋亡以及癌症的发生等过程之间有着直接的联系.本文概括介绍了P300/CbP与PCAf的基本特性,并简要介绍它们与其它蛋白之间的相互作用,特别是E1A的最新研究进展.
    • P38 activation mediates amyloid-beta cytotoxicity 

      Zhu, X. W.; Mei, M.; Lee, H. G.; Wang, Y.; Han, J. H.; Perry, G.; Smith, M. A.; 韩家淮 (2005)
      Amyloid-beta is a leading candidate factor in the development of Alzheimer disease (AD), however the mechanisms involved are unclear. As such, there has been considerable interest in evidence showing that the neuronal ...
    • p38 alpha and p38 gamma Mediate Oncogenic ras-induced Senescence through Differential Mechanisms 

      Kwong, Jinny(Scripps Res Inst, Dept Mol Biol, La Jolla, CA 91037 USA); Hong, Lixin; Liao, Rong(Scripps Res Inst, Dept Mol Biol, La Jolla, CA 91037 USA); Deng, Qingdong(Scripps Res Inst, Dept Mol Biol, La Jolla, CA 91037 USA); Han, Jiahuai; 韩家淮; Sun, Peiqing(Scripps Res Inst, Dept Mol Biol, La Jolla, CA 91037 USA) (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2009)
      Oncogene-induced senescence is a tumor-suppressive defense mechanism triggered upon activation of certain oncogenes in normal cells. Recently, the senescence response to oncogene activation has been shown to act as a bona ...
    • p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation 

      Zohn, I. E.; Li, Y. Q.; Skolnik, E. Y.; Anderson, K. V.; Han, J. H.; Niswander, L.; 韩家淮 (2006)
      During vertebrate gastrulation, an epithelial to mesenchymal transition (EMT) is necessary for migration of mesoderm from the primitive streak. We demonstrate that p38 MAP kinase and a p38-interacting protein (p38IP) are ...
    • P38 beta MAP kinase protects rat mesangial cells from TNF-alpha-induced apoptosis 

      Guo, Y. L.; Kang, B. B.; Han, J. H.; Williamson, J. R.; 韩家淮 (2001)
      p38 MAP kinases (p38) and c-Jun N-terminal protein kinases (INK) have been associated with TNF-alpha -induced apoptosis. However, recent studies indicate that an early but brief activation of INK and/or p38 may actually ...
    • p38 gamma regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage 

      Wu, Chia-Cheng; Wu, Xiaohua; Han, Jiahuai; Sun, Peiqing; 韩家淮 (2010-06)
      In eukaryotic cells, DNA damage triggers activation of checkpoint signaling pathways that coordinate cell cycle arrest and repair of damaged DNA. These DNA damage responses serve to maintain genome stability and prevent ...
    • p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun - The determinant role of the isoforms in the p38 MAPK signal specificity 

      Pramanik, R.; Qi, X. M.; Borowicz, S.; Choubey, D.; Schultz, R. M.; Han, J. H.; Chen, G.; 韩家淮 (2003)
      p38 MAPK pathway signaling is known to participate in cell proliferation, apoptosis, and differentiation, in a manner dependent on the cellular context. The factors that determine the specific biological response in a given ...
    • p38 kinase is a negative regulator of angiotensin II signal transduction in vascular smooth muscle cells - Effects on Na+/H+ exchange and ERK1/2 

      Masatoshi Kusuhara; Eiichi Takahashi; Timothy E.Peterson; Jun-ichi Abe; Mari Ishida; Jiahuai Han; Richard Ulevitch; Bradford C.Berk; 韩家淮 (1998)
      Activation of the Na+/H+ exchanger isoform-1 (NHE-1) by angiotensin II is an early signal transduction event that may regulate vascular smooth muscle cell (VSMC) growth and migration. Many signal transduction events ...
    • P38 kinase-mediated transactivation of the epidermal growth factor receptor is required for dedifferentiation 

      Zhuang, S. G.; Yan, Y.; Han, J. H.; Schnellmann, R. G.; 韩家淮 (2005)
      Renal proximal tubular cell (RPTC) dedifferentiation is thought to be a prerequisite for regenerative proliferation and migration after renal injury. However, the specific mediators and the mechanisms that regulate RPTC ...
    • p38 MAP kinase activation mediates gamma-globin gene induction in erythroid progenitors 

      Pace, B. S.; Qian, X. H.; Sangerman, J.; Ofori-Acquah, S. F.; Baliga, B. S.; Han, J. H.; Critz, S. D.; 韩家淮 (2003)
      Objective. Our goal was to determine the role of p38 mitogen-activated protein kinase (MAPK) signaling in fetal hemoglobin (HbF) induction. Two histone deacetylase inhibitors (HDAIs), sodium butyrate (NB), and trichostatin ...
    • p38 MAP kinase modulates liver cell volume through inhibition of membrane Na+ permeability 

      Feranchak, A. P.; Berl, T.; Capasso, J.; Wojtaszek, P. A.; Han, J. H.; Fitz, J. G.; 韩家淮 (2001)
      In hepatocytes, Na+ influx through nonselective cation (NSC) channels represents a key point for regulation of cell volume. Under basal conditions, channels are closed, but both physiologic and pathologic stimuli lead to ...
    • P38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor 

      Qi, X. M.; Tang, J.; Pramanik, R.; Schultz, R. M.; Shirasawa, S.; Sasazuki, T.; Han, J. H.; Chen, G.; 韩家淮 (2004)
      ras is the most characterized oncogene in human cancer, and yet there are no effective therapeutics to selectively target this oncogene. Our previous work demonstrated the inhibitory activity of the p38 pathway in Ras ...
    • p38 MAPK及其抑制剂在子宫内膜异位症中的作用 

      周卫东; 陈琼华; 陈清西 (2010-05-12)
      子宫内膜异位症(EMs)是与炎症有关的雌激素依赖性疾病。p38丝裂原活化蛋白激酶(p38MAPK)受性激素、炎症因子等因素的激活,在细胞凋亡、增殖、炎症、应激等多种细胞反应中起着重要的作用,并直接参与子宫内膜异位症发生发展过程的调控。p38MAPK信号转导通路在性激素和炎症之间的特殊调节作用,将有助于更好地理解子宫内膜异位症错综复杂的病理假说。p38MAPK抑制剂在子宫内膜异位症的研究中发挥重要作用,且前景广阔。在信号通路水平上阻断和调 ...
    • p38 mitogen-activated protein kinase is involved in Fas ligand expression 

      Hsu, S. C.; Gavrilin, M. A.; Tsai, M. H.; Han, J. H.; Lai, M. Z.; 韩家淮 (1999)
      p38 mitogen-activated protein kinase (MAPK) is activated by T cell receptor engagement. Here we showed that T cell receptor activated p38 alpha but not p38 delta, Inhibition of p38 alpha by the specific inhibitor SE 203580 ...
    • p38 mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase 

      Li, S. P.; Junttila, M. R.; Han, J. H.; Kahari, V. M.; Westermarck, J.; 韩家淮 (2003)
      Cigarette smoking is the most common cause of lung Cancer. The greatest risk of lung cancer is among those who started smoking early in life and continued throughout their lives. However, the molecular mechanisms responsible ...
    • p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression 

      Westermarck, J.; Li, S. P.; Kallunki, T.; Han, J. H.; Kahari, V. M.; 韩家淮 (2001)
      Degradation of collagenous extracellular matrix by collagenase 1 (also known as matrix metalloproteinase 1 [MMP-1]) plays a role in the pathogenesis of various destructive disorders, such as rheumatoid arthritis, chronic ...
    • p38MAPK gene transfection induced the apoptosis of rat glioma cells C6 

      章必成; 李青; 叶菁; 王映梅; 林圣彩 (Journal of Medical Colleges of PLA, 2001)
      Thephosphorylationanddephosphorylationofproteinisoneofthemostimportantmechanismsofcellularsignaltransduction.Theconjugationofphos-phoricacidresiduesandspecificaminoacidresiduesofproteiniscatalyzedbyproteinkinases.Serieso ...
    • p38MAPK与HSP70关系的初步研究 

      王莉(第四军医大学基础部病理学教研室); 李青(第四军医大学基础部病理学教研室; 张丰; 郭爱林(第四军医大学基础部病理学教研室); 叶菁(第四军医大学基础部病理学教研室); 陈广生(第四军医大学基础部病理学教研室); 林圣彩; 樊代明(西京医院消化内科) (第四军医大学, 2002-10)