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South China Sea Bulletin Vol. 7 No.1 (January 2019)
《南海导报》Vol.7 No.1 (2019年1月)
Flexible decapyrrylcorannulene hosts
(Springer Nature Publishing AG, 2019-01)
【Abstract】The assembly of spherical fullerenes, or buckyballs, into single crystals for crystallographic identification often suffers from disordered arrangement. Here we show a chiral configuration of decapyrrylcorannulene ...
Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta
(Elsevier Inc., 2019-01-15)
【Abstract】Dermal fibroblasts (dFBs) resist infection by locallydifferentiating into adipocytes and producing cathe-licidin antimicrobial peptide in response toStaphylo-coccusaureus(S.aureus). Here, we show thatneonatal ...
HBV infection-induced liver cirrhosis development in dual-humanized mice with human bone mesenchymal stem cell transplantation
(BMJ Publishing Group Ltd & British Society of Gastroenterology, 2019-01)
【Abstract】Objective： Developing a small animal model that accurately delineates the natural history of hepatitis B virus (HBV) infection and immunopathophysiology is necessary to clarify the mechanisms of host-virus ...
Comparing mutagenesis and simulations as tools for identifying functionally important sequence changes for protein thermal adaptation
(National Academy of Sciences, 2019-01)
【Abstract】Comparative studies of orthologous proteins of species evolved at different temperatures have revealed consistent patterns of temperature-related variation in thermal stabilities of structure and function. ...
Anti-resonance features of destructive quantum interference in single-molecule thiophene junctions achieved by electrochemical gating
(Springer Nature Publishing AG, 2019-02)
【Abstract】Controlling the electrical conductance and in particular the occurrence of quantum interference in single-molecule junctions through gating effects, has potential for the realization of high-performance functional ...
Pharmacological targeting of STK19 inhibits oncogenic NRAS driven melanomagenesis
(Elsevier Inc., 2019-01)
【Abstract】Activating mutations in NRAS account for 20-30% of melanoma, but despite decades of research and in contrast to BRAF, no effective anti-NRAS therapies have been forthcoming. Here we identify a previously unch ...