Now showing items 1-2 of 2

    • Nickel(II)-Magnesium-Catalyzed Cross-Coupling of 1,1-Dibromo-1-alkenes with Diphenylphosphine Oxide: One-Pot Synthesis of (E)-1-Alkenylphosphine Oxides or Bisphosphine Oxides 

      Liu, Liu; Wang, Yulei; Zeng, Zhiping; Xu, Pengxiang; Gao, Yuxing; Yin, Yingwu; Zhao, Yufen; 曾志平; 许鹏翔; 高玉兴; 尹应武; 赵玉芬 (WILEY-V C H VERLAG GMBH, 2013)
      A novel nickel(II)-magnesium-mediated cross-coupling of diphenylphosphine oxide with a variety of 1,1-dibromo-1-alkenes has been developed, which provides a powerful and general methodology for the stereoselective synthesis ...
    • 肿瘤微环境诱导胃癌化疗耐药的机制研究 

      庄新国 (2015-04-16)
      摘要 【背景和目的】化疗是临床治疗胃癌的重要手段,但在临床上胃癌常对化疗表现出耐药,甚至多重耐药(Multidrugresistance,MDR)。研究发现,很多化疗药物在体外试验中对胃癌细胞有较好的杀伤效果,而在临床治疗中,其对胃癌的治疗效果却不理想。肿瘤微环境是胃癌的化疗效果在体内和体外产生差异的重要原因;已证实肿瘤微环境中的IL-6、IL-8、氧分压等因素对胃癌耐药有一定影响,但肿瘤微环境整体对胃癌耐药的影响及内在机制仍不清楚。为 ...