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  • Chia-Chen Liu; Chih-Wei Tsai; Ferenc Deak; Justin Rogers; Michael Penuliar; You Me Sung; James N. Maher; Yuan Fu; Xia Li; Huaxi Xu; 许华曦; Steven Estus; Hyang-Sook Hoe; John D. Fryer; Takahisa Kanekiyo; Guojun Bu; 卜国军 (Elsevier Inc., 2014-09-18)
    Alzheimer’s disease (AD) is an age-related neurological disorder characterized by synaptic loss and dementia. The low-density lipoprotein receptor-related protein 6 (LRP6) is an essential coreceptor for Wnt signaling, and ...
  • Meilin Wang; 王梅林; Lei Guo; 郭磊; Qingang Wu; 吴勤刚; Taoling Zeng; Qi Lin; Yikai Qiao; Qun Wang; Mingdong Liu; Xin Zhang; Lan Ren; Sheng Zhang; Yihua Pei; Zhenyu Yin; Feng Ding; Hong-Rui Wang; 王洪睿 (Nature Publishing Group, 2014-09-24)
    ​ATM- and RAD3-related (​ATR)/​Chk1 and ​ataxia–telangiectasia mutated (​ATM)/​Chk2 signalling pathways play critical roles in the DNA damage response. Here we report that the E3 ubiquitin ligase ​Smurf1 determines cell ...
  • Peng-Fei Ma; 马鹏飞; Jie Jiang; 姜杰; Chang Gao; Pan-Pan Cheng; Jia-Li Li; Xin Huang; Ying-Ying Lin; Qing Li; Yuan-Zheng Peng; 彭园征; Mei-Chun Cai; Wei Shao; 邵巍; Qi Zhu; Sai Han; Qing Qin; Jun-Jie Xia; 夏俊杰; Zhong-Quan Qi; 齐忠权 (American Diabetes Association, 2014-05-16)
    Islet transplantation is a therapeutic option for type 1 diabetes, but its long-term success is limited by islet allograft survival. Many factors imperil islet survival, especially the adverse effects and toxicity due to ...
  • Chia-Chen Liu; Kanekiyo Takahisa; Barbara Roth; Guojun Bu; 卜国军 (American Society for Biochemistry and Molecular Biology, 2014-08-20)
    Wnt/β-catenin signaling orchestrates a number of critical events including cell growth, differentiation and cell survival during development. Misregulation of this pathway leads to various human diseases, specifically ...
  • Chen-Song Zhang; Bin Jiang; Mengqi Li; Mingjiang Zhu; Yongying Peng; Ya-Lin Zhang; Yu-Qing Wu; Terytty Yang Li; Yu Liang; Zailian Lu; 卢再恋; Guili Lian; Qing Liu; Huiling Guo; 郭慧玲; Zhenyu Yin; Zhiyun Ye; 叶志云; Jiahuai Han; 韩家淮; Jia-Wei Wu; Huiyong Yin; Shu-Yong Lin; 林舒勇; Sheng-Cai Lin; 林圣彩 (Elsevier Inc., 2014-07-03)
    AMPK and mTOR play principal roles in governing metabolic programs; however, mechanisms underlying the coordination of the two inversely regulated kinases remain unclear. In this study we found, most surprisingly, that the ...

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